Mark Curry's first role was in the film Talkin' Dirty After Dark, alongside Martin Lawrence in 1991. In 1992, Curry's first major role was on television series Hangin' with Mr. Cooper, where he played the lead role of Mark Cooper, an NBA player-turned-substitute teacher/gym coach. Curry appeared two episodes of The Jamie Foxx Show as eccentric driving instructor Sergeant Easy. In addition, he also had guest starring roles on television series Living Single in 1994 and Martin in 1997, and minor roles in the films Switchback and Armageddon in 1998. In 2000, Curry also had a recurring role on The Drew Carey Show as Drew's boss at Winfred-Louder. He appeared in six episodes. In an April Fools' episode of The Drew Carey Show, Drew refers to Mr. Soulard as Mr. Cooper, the joke being that Curry played both roles.
He was the host of Comedy Central's Don't Forget Your Toothbrush in 2000 and had minor roles in For Your Love, which starred Hangin' with Mr. Cooper co-star, Holly Robinson Peete). Also, in 2000, Curry starred in A Man Is Mostly Water. In 2001 had a minor role in the Disney Channel Original Movie Motocrossed. Later in the year, Curry played one of the leads in another Disney Channel Original Movie, The Poof Point. Curry was the host of the PAX-TV show Animal Tails and BET's "Coming to the Stage" in 2003. In 2004, he appeared on Celebrity Mole Yucatan. He came in second place to Dennis Rodman. In 2005, had guest starring roles in Less Than Perfect and Fat Actress.
On November 30, 2008, Mark performed a stand-up comedy routine on The Comedy Festival Laffapalooza Special, hosted by Tracy Morgan. In 2009-2011, Curry hosted Jamie Foxx's "FoxxHole Live" every Monday in the Conga Room in Los Angeles, which was heard on Satellite Radio sirus 106/XM 149. In 2012, Curry joined Sommore, Earthquake, Bruce Bruce and Tony Rock on the "Royal Comedy Tour." Many spectators have viewed Curry's stand-up comedy performance as the highlight of the show leaving the audience in hysterical laughter. As of 2013, Curry is still on the Royal Comedy Tour.
Later in 2012, Curry joined Nick At Nite's first-ever original live-action family comedy series, See Dad Run as Scott Baio's friend Marcus. On December 19, 2012. Nick at Nite renewed the series for a second season of 20 episodes.